基于裂隙灯的眼微血管形态学参数分析在眼科疾病诊断的应用

Application of morphological parameters analysis of ophthalmic microvasculature based on slit lamp in the diagnosis of ophthalmic diseases

目的:实现眼微血管分析系统及其在结膜眼病等的应用研究。方法:将高速摄像头与视频采集卡等数字图像采集装置集成到标准裂隙灯平台上,开发一种临床友好型多功能眼表微血管成像平台;研发图像分析软件对时差影像解析和图像分形分析,对血管形态学包括血管形态改变及密度、复杂程度进行分级定量。结果:整套系统功能完备、工作稳定,建立快速分析结膜微血管血流参数及血管形态参数分析模型,可分析患者致病因素与微血管功能的相关性。结论:血管网络的分形、形态学和人体结膜血流动力学可以使用功能性裂隙灯生物显微镜轻松可靠地测量。分形维数差别可能反应一定的疾病,进行非接触性指标和分析,探讨检测指标的特异性和敏感性,对眼科微血管功能相关疾病及全身疾病的诊断均具有重要意义。

Objective To develop the analysis system of ophthalmic microvasculature and explore its application in conjunctival ophthalmopathy. Methods A friendly clinical multifunctional ophthalmic microvascular imaging platform was developed by integrating digital image acquisition device including high-speed camera and video capture card into standard slit lamp on the platform. The image analysis software was used for analyzing the images and image fractal difference, and quantitatively classifying vascular morphology including vascular morphology, density and complexity. Results The whole system was fully functional and stable. A model for the rapid analysis of blood flow parameters and morphological parameters of blood vessels was established, and the correlation between the pathogenic factors and microvascular functions was analyzed. Conclusion The fi＇actal, morphological, and human conjunctival hemodynamics of the vascular network can be easily and reliably measured using functional slit lamp biomicroscope. The differences in fractal dimension may reflect certain diseases. Measuring and analyzing non-contact detection indicators, and discussing the specificity and sensitivity of detection indicators are of great importance in the ophthalmic diagnosis of microvascular function-related diseases and systemic diseases.