摘要
目的评价卡培他滨维持治疗对复发转移三阴性乳腺癌的临床疗效。方法选取2012年1月2016年1月瓦房店市中心医院就诊并确诊的72例复发转移三阴性乳腺癌患者作为研究对象,随机分为观察组和对照组各36例。观察组在一线化疗后给予卡培他滨维持治疗,对照组给予其他支持治疗,随访观察并评价两组的治疗效果、无进展生存时间及观察组的不良反应发生情况。结果观察组的总有效率及疾病控制率均高于对照组,差异有统计学意义(P〈0.05)。观察组的中位无进展生存期比对照组长,差异有统计学意义(P〈0.05)。观察组发生的主要不良反应为胃肠道反应、血小板减少、粒细胞减少、手足综合征及肝肾功能损害,严重程度多为Ⅰ-Ⅱ级,未出现严重不良反应。结论卡培他滨维持治疗复发转移三阴性乳腺癌患者的疗效较好,可延长其无进展生存时间,不良反应可耐受。
Objective To investigate the clinical effect of capecitabine maintenance therapy for recurrence and metastasis of triple-negative breast cancer. Methods A total of 72 triple-negative breast cancer patients with recurrence and metastasis were collected in Wanfangdian Central Hospital from January 1, 2012 to January 1,2016, and were randomized into two groups: study group (n=36) and control group (n=36). Based on the first-line chemotherapy, the patients in study group were treated with capecitabine maintenance therapy, while the patients in control group were treated with other supportive therapy. The clinical effect, progress-free survival time (PFS), and adverse reaction were compared between two groups during the follow-up visit. Results The total effect rate and disease control rate in study group were significantly higher than those in control group (P〈0.05). The median PFS time in study group was significantly longer than that in control group (P〈0.05). The main adverse reaction in study group were gastrointestinal reaction, thrombocytopenia, granulocytopenia, hand-foot syndrome and liver and kidney function damage, but limiting to level Ⅰ-Ⅱ, and no serious adverse reaction happened. Conclusion Capecitabine maintenance therapy has a good clinical effect on recurrence and metastasis of triple-negative breast cancer, prolong the PFS time, and no serious adverse reaction.
作者
田华
TIAN Hua(The Third Department of Medical Oncology, Wanfangdian Central Hospital, Dalian, 116300, Liaoning Province, Chin)
出处
《中国实用乡村医生杂志》
2018年第3期63-66,共4页
Chinese Practical Journal of Rural Doctor
关键词
乳腺癌
卡培他滨
维持治疗
Breast Cancer
Capecitabine
Maintenance Therapy