阿尔茨海默病及其他痴呆诊断与治疗临床转化研究进展

Progress of translational research on the diagnosis and treatment of Alzheimer's disease and other dementias

阿尔茨海默病是临床最常见的神经变性病,通常65岁以后缓慢起病,表现为以记忆障碍为主的认知功能障碍,进行性加重并难以逆转,最终导致痴呆和功能障碍,故早期诊断、及时治疗和有效预防成为重要临床和科研问题。我国国民经济和社会发展第十二个五年规划(简称"十二五")时期,上海交通大学医学院附属瑞金医院陈生弟教授研究团队长期致力于阿尔茨海默病的诊断与治疗研究,开展包括发病机制、流行病学和危险因素筛查、神经心理学测验、影像学和生物学标志物、早期干预等研究,本文拟就上述研究成果进行简要综述。

Alzheimer＇s disease（AD） is one of most common neurodegenerative diseases, whichgradually begins and develops after 65 years old, presenting as progressive and irreversible memory lossand other cognitive decline, and finally causes dementia and disability. Therefore, early diagnosis, timelytreatment and effective prevention of AD have been become important clinical and scientific problems.During the period of Twelfth Five-Year Plan for National Economic and Social Development, our team haveengaged in AD diagnosis and treatment for a long time and carried out studies in the field of pathogenesis,epidemiology, screening of risk factors, neuropsychological tests, imaging, biomarkers and early interventionof AD. This paper has summarized these research achievements.