重复经颅磁刺激对脑损伤患儿的临床疗效研究

Clinical study of repetitive transcranial magnetic stimulation on the brain injury in infants

目的研究重复经颅磁刺激(rTMS)对神经损伤患儿的早期干预应用价值。方法通过前瞻性随机对照试验,选取46例脑损伤患儿,随机分为治疗组和对照组。两组均进行基础干预,观察组同时加用rTMS,分别于干预前及干预3个小疗程后对患儿进行相关功能评价。结果治疗前后比较显示,两组GMFM-88量表、Peabody量表的GMQ及FMQ评分较治疗前明显提高(P<0.05);治疗后观察组的GMFM-88量表、Peabody量表的GMQ及FMQ评分较对照组提高明显,其中Peabody量表的GMQ得分差异有统计学意义(P<0.05)。观察组治疗后,睡眠总体印象、夜间觉醒/哭闹次数较治疗前好转(P<0.05)。午睡时间、晚间入睡困难、夜间睡眠时间、早晨醒后哭闹无明显变化(P>0.05)。结论重复经颅磁刺激对神经损伤患儿的脑功能康复有一定的效果,值得应用。

Objective To explore the application value of repetitive transcranial magnetic stimulation （rTMS） on the children with brain injury. Methods Through prospective randomized controlled trials, 46 cases of brain injury infants were randomly divided into treatment group and control group. The two groups were both given basic intervention, and the observation group were added with rTMS,and the related {unction were evaluated before and after the trial. Results Af- ter treatment,GMFM-88 and Peabody scale GMQ and GMQ score in two groups were significantly improved than those be- fore treatment （P-0.05） ;After treatment, GMFM-88, GMQ and FMQ score in Peabody Scale of the observation group in- creased obviously than those of the control group,and there were significant differences on the scores of GMQ （P-0.05）. After treatment,the overall sleep and waking up or crying at night were better than the those before treatment （P〈0.05）. Nap time, difficulty in failing asleep at night, sleep time at night, waking up crying in the morning did not change significant- ly （P-0.05）. Conclusion rTMS therapy has a certain effect on the recovery of brain function in children with brain injury.