海南暗罗根生物碱类成分研究

Alkaloids from the Roots of Polyalthia laui

目的:研究海南暗罗根的化学成分。方法:运用硅胶柱层析、Sephadex LH-20柱色谱、半制备高效液相色谱等方法进行分离纯化,通过理化性质和波谱数据鉴定化合物结构。结果:从海南暗罗根中分离得到11个生物碱类成分,分别鉴定为:isooncodine(1)、onychine(2)、5,8-dihydroxy-6-methoxy onychine(3)、darienine(4)、O-methylmoschatoline(5)、isomoschatolin(6)、oxostephanine(7)、liriodenine(8)、N-p-coumaroyltyramine(9)、northalifoline(10)、corydaldine(11)。结论:所有化合物均为首次从该植物中分离得到,化合物3、6、10、11为首次从暗罗属植物中分离得到。

Objective： To investigate the chemical constituents from the roots of Polyalthia laui. Methods： The constituents from Polyalthia laui were isolated and purified by the chromatography on silica gel,Sephadex LH-20,and semi preparation HPLC. Their structures were identified on the basis of physiochemical characteristics and spectroscopic data analysis. Results： Eleven alkaloids were isolated from the roots of Polyalthia laui and identified as isooncodine（ 1）,onychine（ 2）,5,8-dihydroxy-6-methoxy onychine（ 3）,darienine（ 4）,O-methylmoschatoline（ 5）,isomoschatolin（ 6）,oxostephanine（ 7）,liriodenine（ 8）,N-p-coumaroyltyramine（ 9）,northalifoline（ 10） and corydaldine（ 11）. Conclusion： All the compounds are isolated from this plant for the first time,compounds 3,6,10,11 are reported from the Polyalthia genus for the first time.