发作性睡病中医证候研究概况

Research situation about traditional Chinese medicine syndrome types of narcolepsy

发作性睡病在国际上的研究已比较深入,而国内研究尚在起步阶段,该病的发病率呈上升趋势。目前发作性睡病的中医证候分类尚未规范统一,准确的辨证有助于提高中医药临床疗效。文章从证候分类、不同分型的证候分布特点及证候与HLA-DQB1易感基因相关性等方面概括发作性睡病证候研究。结果发现发作性睡病的证候分类主要为单证证候和复合证候,证候在早发型和晚发型有不同的分布特点,证候与HLA-DQB1易感基因存在相关性。在前期研究基础上,应尽快建立规范化的发作性睡病证候标准,指导中医药治疗发作性睡病的临床和基础研究。

The study of narcolepsy is very comprehensive abroad while initial at home. The incidence rate of narcolepsy has risen in recent years. Appropriate syndrome differentiation develops the clinical effect of traditional Chinese medicine （TCM） in treating narcolepsy, while the criterion of the TCM syndrome classification of narcolepsy has not been established at present. Syndrome researches of narcolepsy were summarized from the following aspects, such as syndrome classification, characteristics of TCM syndrome type distribution in different disease types, relationship between syndrome and the susceptible gene of HLA- DQB 1. The study concluded that the syndrome classification of narcolepsy mainly includes single or composite syndromes, syndrome distribution bad different characteristics between early-onset and late-onset narcolepsy. Besides, syndrome and the susceptible gene of HLA-DQB 1 were correlations. Standards for syndromes of narcolepsy should be established recently based on previous research for providing guidance in clinical and basic research on TCM treatment of narcolepsy.