从痰瘀论治血脂异常的文献研究

Literature study on dyslipidemia based on phlegm and blood stasis

目的:通过分析中医药相关文献,探讨血脂异常的中医证候分布规律和用药规律。方法:利用中国期刊全文数据库(CNKI)对1997年6月至2016年9月的中医药期刊文献所报道的血脂异常的相关文章进行检索,对其中涉及血脂异常的证型、治则、用药规律进行统计分析。结果:共检出文献872篇,符合纳入标准的为169篇;其中有关中医证型的137篇文献中,经统计共有35种证候,以痰瘀互结证为主,所占比例最多,约为32.12%。病位类证候要素共5种,以脾多见,约占总体的50.00%,病性类证候要素共10种,以痰浊、血瘀多见,分别占总体的42.92%、30.83%。涉及用药的169篇文献中以山楂、丹参、泽泻等为主,前20位药物中有祛痰功效的4味,约占总体的12.19%,有化瘀功效的6味,约占总体的16.51%。结论:血脂异常中医证候分布以痰瘀互结证最多,病性类证候要素也显示以"痰""瘀"多见。用药排在前20位的药物,多为祛痰药和化瘀药。提示血脂异常可从痰瘀角度论治。

Objective： To explore the regularity of TCM syndrome distribution and the rule of drug use by analyzing the related literature of traditional Chinese medicine. Methods： The related articles of dyslipidemia reported in Chinese medicine journal literature in June 1997 to September 2016 were retrieved by Chinese journal full text database CNKI, and the syndrome types, treatment rules and medication rules of dyslipidemia were statistically analyzed. Results： A total of 878 articles were identified, 169 of which were in line with the inclusion criteria of Na. Among the 137 TCM syndromes, there were 35 syndromes, mainly composed of phlegm and blood stasis syndrome, accounting for about 32.12% of the total. There were 5 kinds of syndromes of the disease, which were mostly seen in the spleen, accounting for about 50.00% of the total. There were 10 kinds of disease syndrome factors, which were mainly phlegm and blood stasis, which accounted for 42.92% and 30.83% of the total. There were 169 drugs involved in hawthorn, Salvia miltiorrhiza, Alisma and Alisma orientalis, the first 20 drugs had the expectorant effect of 4, accounting for about 19.53% of the total. There were six flavors with the efficacy of removing blood stasis, accounting for about 16.51% of the total. Conclusion： Syndrome distribution of dyslipidemia is the most common syndrome of phlegm and blood stasis, and the symptoms of disease syndrome also show that ＇phlegm＇ and ＇blood stasis＇ are common. The drugs used in the first 20 places are mostly expectorant and drug-removing drugs. It is suggested that the abnormal blood lipid can be treated from the angle of phlegm and blood stasis.