清热活血方药对过敏性紫癜肾炎患儿t-PA和PAI-1水平的影响

Effects of Heat-clearing and Blood-activating Formula on the levels of t-PA and PAI-1 in children with nephritis of anaphylactoid purpura

目的:通过观察过敏性紫癜肾炎患儿使用清热活血方药治疗前后纤溶系统标志物——组织纤维溶酶原激活物(t-PA)和血浆纤溶酶原激活物抑制剂-1(PAI-1)的变化,分析该方药对过敏性紫癜肾炎患儿纤溶系统的影响。方法:测定治疗前后24h尿蛋白定量、t-PA与PAI-1含量。结果:两组24h尿蛋白定量治疗后较治疗前显著降低(P<0.01),两组治疗后t-PA含量较治疗前显著增加(P<0.01),PAI-1水平较治疗前均显著减低(P<0.01),治疗组与对照组比较,差异有统计学意义(P<0.01)。结论:清热活血方药可以改善过敏性紫癜肾炎患儿的纤溶系统。

Objective： To observe the changes of fibrinolytic system markers in children with Henoch-Schonlein purpura nephritis before and after treatment of Heat-clearing and Blood-activating Formula, and to analyze its effect on fibrinolytic system in children with Henoch-Schonlein purpura nephritis. Methods： The content of 24h urinary protein quantification, t-PA and PAI-1 before and after treatment were measured. Results： The content of 24h urinary protein quantification in two groups were significanty lower than that before the treatment （P〈0.01）. The content of t-PA in the treatment group was significantly higher than that before the treatment （P〈0.01）, and the level of PAI-1 was significantly lower than that before the treatment （P〈0.01）. There was a significant difference between the treatment group and the control group （P〈0.01）. Conclusion： Heat-clearing and Blood- activating Formula can improve the fibrinolytic system of children with nephritis of anaphylactoid purpura.