脂肪干细胞对神经创伤修复的研究进展

Research Pogress of Adipose Derived Stem Cells on Nerve Injury Repair

在医学上,神经系统对神经损伤的自我修复能力往往有限。因此,探索有效修复损伤神经的方法已经成为近年来的研究热点。研究发现脂肪干细胞对各类损伤神经都有一定的修复作用,可作为修复神经损伤的种子细胞。脂肪干细胞不仅具有干细胞的特性而且还具有自身的优点;首先它属于成体细胞,来源于中胚层,具有多种分化的潜能;其次免疫原性较低,易于取材;另外脂肪干细胞移植后的风险较低,因此被认为是修复神经损伤的优秀种子细胞。就脂肪干细胞的特性及脂肪干细胞在神经创伤修复方面的研究进展和存在的问题进行综述。

In medicine,the ability of the nervous system to repair nerve damage is often limited. In recent years,it has been found that adipose derived stem cells（ ADSCs） have repair effects on various types of nerve injury and can be the seed cells for nerve injury repair. Not only being as stem cells,ADSCs also have some exclusive advantages. ADSCs belong to adult cells,which derived from the mesoderm,with multi-lineage differentiation potential,low immunogenicity,easy to gain,low risk after transplantation,thus make them become excellent immunogenicity,easy to gain,low risk after transplantation,thus make them become excellent seed cells for the nerve repair. The characteristics of adipose derived stem cells and their research progress and existing problems on nerve injury repair were reviewed.