抗肿瘤重组蛋白疫苗的研究进展

Research progress of anti-tumor recombinant protein vaccines

肿瘤疫苗包括肽或蛋白疫苗、肿瘤细胞疫苗、抗独特型疫苗、树突状细胞疫苗、DNA疫苗及病毒载体类疫苗等.重组蛋白疫苗是通过对目的抗原基因的重组、构建、表达得到抗原蛋白,最终制备成的疫苗.随着重组技术及表达纯化技术的日益成熟,重组蛋白疫苗为肿瘤免疫治疗研究提供了一种研发思路.此文针对肿瘤抗原的重组蛋白疫苗做一综述.

Tumor vaccines include peptide or protein vaccine,tumor cell vaccine,anti-idiotype vaccine,dendritic cell vaccine,DNA vaccine and viral-vector based vaccine.The recombinant protein vaccine is prepared by the recombination,construction,and expression of target antigen gene.With the development of recombination,expression and purification technologies,recombinant protein vaccine provides a research and development method for tumor immunotherapy study.This article reviews on the recombinant protein vaccine of tumor antigen.