猪肺磷脂注射液联合辅助通气治疗足月新生儿急性呼吸窘迫综合征的疗效观察

Observation on Efficacy of Pulmonary Surfactant Injections Combined with Adjuvant Ventilation in Treatment of Full-term Neonatal Acute Respiratory Distress Syndrome

目的:探讨猪肺磷脂注射液联合辅助通气治疗足月新生儿急性呼吸窘迫综合征的临床疗效。方法:选取2016年1月—2017年1月湖北省谷城县人民医院收治的足月新生儿急性呼吸窘迫综合征患者80例,采用随机信封法分为观察组和对照组,每组40例。对照组患儿给予常规辅助通气治疗,观察组患儿给予猪肺磷脂注射液联合辅助通气治疗。观察两组患儿最高平均动脉压(MAP)水平、机械通气时间、高浓度氧持续时间、体征恢复时间、住院时间、死亡率及并发症发生情况。结果:治疗后,观察组患儿最高MAP水平明显低于对照组,机械通气时间、高浓度氧持续时间、体征恢复时间和住院时间明显短于对照组,差异均有统计学意义(P<0.05);观察组患儿死亡率为12.50%(5/40),明显低于对照组的40.00%(16/40),差异有统计学意义(P<0.05);观察组患儿并发症发生率为12.50%(5/40),明显低于对照组的50.00%(20/40),差异有统计学意义(P<0.05)。结论:猪肺磷脂注射液联合辅助通气治疗足月新生儿急性呼吸窘迫综合征的疗效显著。

OBJECTIVE： To probe into the clinical efficacy of pulmonary surfactant injections combined with adjuvant ventilation in treatment of full-term neonatal acute respiratory distress syndrome. METHODS： 80 patients with full-term neonatal acute respiratory distress syndrome admitted into Hubei Gucheng County People＇s Hospital from Jan.2016 to Jan. 2017 were extracted to be divided into observation group and control group via the random envelope method,with 40 cases in each. The control group was given conventional adjuvant ventilation,while the observation group received pulmonary surfactant injections combined with adjuvant ventilation. The highest MAP level,mechanical ventilation time,high oxygen duration,physical recovery time,length of stay,clinical efficacy and incidence of complication of two groups were observed. RESULTS： After treatment,the highest mean arterial pressure（ MAP） level of observation group was significantly lower than that of control group,yet the mechanical ventilation time,high oxygen duration,physical recovery time,length of stay of observation group were significantly shorter than those of control group,with statistically significant difference（ P 0. 05）. The death rate of observation group was 12. 50%（ 5/40）,significantly lower than that of control group [40. 00%（ 16/40） ],with statistically significant difference（ P 0. 05）.The incidence of complication of observation group was 12. 50%（ 5/40）,significantly lower than that of control group[50. 00%（ 20/40） ],with statistically significant difference（ P 0. 05）. CONCLUSIONS： The efficacy of pulmonary surfactant injections combined with adjuvant ventilation in treatment of full-term neonatal acute respiratory distress syndrome is remarkable.