不同剂量羟考酮用于晚期恶性肿瘤患者的镇痛效果及安全性

Analgesic Effects and Safety of Different Doses of Oxycodone in Treatment of Patients with Advanced Malignant Tumor

目的:探讨不同剂量羟考酮用于晚期恶性肿瘤患者的镇痛效果及安全性。方法:选取2014年5月—2016年11月郑州市第三人民医院收治的晚期恶性肿瘤患者80例,以随机数字表法分为A、B组,每组40例。A、B组患者分别给予盐酸羟考酮缓释片20 mg/12 h、150 mg/12 h,1日2次,进行镇痛治疗。观察两组患者的镇痛效果、疼痛视觉模拟评分、生活质量评分和不良反应发生情况。结果:A组患者的镇痛总有效率为95.0%(38/40),明显高于B组的82.5%(33/40),差异有统计学意义(P<0.05);治疗7 d、治疗结束2周后,A组患者视觉模拟评分明显高于B组,差异均有统计学意义(P<0.05);治疗后,B组患者各项生活质量评分明显高于A组,差异均有统计学意义(P<0.05);两组患者恶心呕吐、嗜睡乏力、头晕和其他不良反应发生率的差异均无统计学意义(P>0.05)。结论:羟考酮用于晚期恶性肿瘤患者的镇痛效果显著,而大剂量羟考酮在控制疼痛上更具优越性,且可显著改善患者的生活质量,不良反应在可耐受范围内。

OBJECTIVE： To probe into the analgesic effects and safety of different doses of oxycodone in treatment of patients with advanced malignant tumor. METHODS： 80 patients with advanced malignant tumor admitted into the Third People＇s Hospital of Zhengzhou from May 2014 to Nov. 2016 were extracted to be divided into group A and group B via the random number table,with 40 cases in each. Patients in group A and group B were respectively given oxycodone 20 mg/12 h and 150 mg/12 h,twice a day,for pain treatment. The analgesic effect,visual analogue scale（ VAS） score,life quality score and incidence of adverse drug reactions of two groups were observed. RESULTS： The total analgesic effective rate of group A was 95. 0 %（ 38/40）,significantly higher than that of control group [82. 5 %（ 33/40） ],with statistically significant difference（ P 0. 05）. After treatment of 7 d and 2 weeks after the end of the treatment,the VAS score of group A was significantly higher than that of group B,with statistically significant difference（ P 0. 05）. After treatment,the life quality score of group B was significantly higher than that of group A,with statistically significant difference（ P 0. 05）. There was no statistically significant difference between two groups in nausea and vomiting,drowsiness fatigue,swirl and other incidence of adverse drug reactions（ P 0. 05）. CONCLUSIONS： The analgesic effects of oxycodone in treatment of patients with advanced malignant tumor is significant,and high-dose intervention has more advantages in the control of pain; in addition,oxycodone can improve the quality of life of patients,and the adverse drug reactions are in the tolerance range.