门冬氨酸钾镁与胺碘酮联合治疗急性心肌梗死并发室性心律失常的疗效观察

Observation on Efficacy of Amiodarone Combined with Potassium and Magnesium Aspartate in Treatment of Acute Myocardial Infarction Complicated with Ventricular Arrhythmia

目的:探讨门冬氨酸钾镁与胺碘酮联合治疗急性心肌梗死并发室性心律失常的临床疗效及安全性。方法:选取2015年10月—2017年10月解放军第九八医院收治的急性心肌梗死并发室性心律失常患者100例,通过电脑软件随机分为对照组与观察组,每组50例,对照组患者给予胺碘酮治疗,观察组患者在对照组基础上加用门冬氨酸钾镁,比较两组患者的疗效、心电图检查指标水平、实验室检查指标水平及不良反应发生情况。结果:观察组患者的总有效率为94%(47/50),明显高于对照组的82%(41/50),差异有统计学意义(P<0.05);治疗后,观察组患者的心电图检查指标、实验室检查指标改善程度明显优于对照组,差异均有统计学意义(P<0.05);观察组患者不良反应发生率为6%(3/50),明显低于对照组的18%(9/50),差异有统计学意义(P<0.05)。结论:门冬氨酸钾镁与胺碘酮联合治疗急性心肌梗死并发室性心律失常,可提高疗效,改善心电图指标和实验室指标,不良反应少。

OBJECTIVE： To probe into the clinical efficacy and safety of amiodarone combined with potassium and magnesium aspartate in treatment of acute myocardial infarction complicated with ventricular arrhythmia. METHODS：100 patients with acute myocardial infarction complicated with ventricular arrhythmia admitted into Liberation Army No.98 Hospital from Oct. 2015 to Oct. 2017 were extracted to be divided into control group and observation group via the computer software,with 50 cases in each. The control group was given amiodarone,while the observation group additionally received potassium and magnesium aspartate based on the control group. The efficacy,electrocardiogram examination indicators and laboratory inspection indicators and incidence of adverse drug reactions of two groups were compared. RESULTS： The total effective rate of observation group was 94%（ 47/50）,significantly higher than that of control group [82%（ 41/50） ],with statistically significant difference（ P 0. 05）. After treatment,the improvement of electrocardiogram examination indicators and laboratory inspection indicators of observation group were significantly better than those of control group,with statistically significant difference（ P 0. 05）. The incidence of adverse drug reactions of observation group was 6%（ 3/50）,significantly lower than that of control group [18%（ 9/50） ],with statistically significant difference（ P 0. 05）. CONCLUSIONS： Amiodarone combined with potassium and magnesium aspartate in treatment of acute myocardial infarction complicated with ventricular arrhythmia can promote the efficacy and improve the electrocardiogram examination indicators and laboratory inspection indicators with few adverse drug reactions.