索利那新联合坦索罗辛治疗良性前列腺增生伴下尿路症状的疗效及安全性

Efficacy and Safety of Solifenacin Combined with Tamsulosin in Treatment of Patients with Benign Prostatic Hyperplasia Complicated with Lower Urinary Tract Symptoms

目的:探讨索利那新联合坦索罗辛治疗良性前列腺增生伴下尿路症状的疗效及安全性。方法:选取2015年7月—2017年7月湖北省公安县人民医院收治的良性前列腺增生伴下尿路症状患者80例,按照入院顺序分组,奇数为对照组,偶数为观察组,每组40例。对照组患者口服坦索罗辛,观察组患者在对照组的基础上加用索利那新。观察两组患者治疗前后储尿期症状评分、国际前列腺症状评分、生活质量评分、最大尿流率、膀胱残余尿量及不良反应发生情况。结果:治疗后,观察组患者储尿期症状评分、国际前列腺症状评分、生活质量评分及膀胱残余尿量明显低于治疗前及对照组治疗后,最大尿流率明显高于治疗前及对照组治疗后,差异均有统计学意义(P<0.05);观察组、对照组患者不良反应发生率分别为14.0%(7/40)、12.0%(6/40),差异无统计学意义(P>0.05)。结论:索利那新联合坦索罗辛治疗良性前列腺增生伴下尿路症状的疗效显著,安全性较高。

OBJECTIVE： To probe into the efficacy and safety of solifenacin combined with tamsulosin in treatment of patient with benign prostatic hyperplasia complicated with lower urinary tract symptoms. METHODS： 80 patients with benign prostatic hyperplasia complicated with lower urinary tract symptoms admitted into Hubei Gongan County People＇s Hospital from Jul. 2015 to Jul. 2017 were according to admission order grouping,odd number as the control group,even number as the observation group,with 40 cases in each. The control group was given oral tamsulosin,while the observation group additionally received solifenacin based on the control group. The symptom score of urine storage period,international prostate symptom score,life quality score,maximum urinary flow rate,bladder residual urine volume and incidence of adverse drug reactions of two groups were observed before and after treatment.RESULTS： After treatment,the symptom score of urine storage period,international prostate symptom score,life quality score and bladder residual urine volume of observation group were significantly lower than before treatment and control group after treatment,yet the maximum urinary flow rate was higher than before treatment and control group after treatment,with statistically significant difference（ P 0. 05）. The incidence of adverse drug reactions of observation group and control group were respectively 14. 0%（ 7/40） and 12. 0%（ 6/40）,without any statistical significance（ P 0. 05）. CONCLUSIONS： The efficacy of solifenacin combined with tamsulosin in treatment of patient with benign prostatic hyperplasia complicated with lower urinary tract symptoms is remarkable with higher safety.