孟鲁司特钠联合匹多莫德治疗对反复呼吸道感染患儿肺功能及免疫功能的影响

Effects of montelukast sodium combined with pidotimer on pulmonary function and immune function in children with recurrent respiratory tract infections

目的探究孟鲁司特钠联合匹多莫德治疗对反复呼吸道感染(recurrent respiratory tract infections,RRTI)患儿肺功能及免疫功能的影响。方法选取2015年1月至2016年1月间就诊于海军总医院儿科门诊的RRTI患儿78例,根据随机数字法将其分为对照组和观察组,各39例。2组患者均予以匹多莫德,口服,予雾化治疗及积极抗感染等一般常规治疗,在此基础上,观察组患者予以口服孟鲁司特钠治疗,疗程3个月。疗程结束后,比较2组患者治疗总有效率、临床症候、肺功能、免疫功能。结果观察组患者治疗有效率(94.87%)明显高于对照组(61.54%),差异具有统计学意义(χ2=12.71,P=0.00);观察组咳嗽消失时间明显短于对照组,差异有统计学意义(t=5.82,P=0.00);观察组喘息消失、退热、肺内啰音消失的时间均低于对照组,但差异均无统计学意义(P>0.05);2组患者治疗后用力肺活量、1秒用力呼气容积、1秒用力呼气容积/用力肺活量、50%最大呼气流量和最大呼气流量水平明显高于治疗前,且观察组明显高于对照组,差异均有统计学意义(P<0.05);2组患者血清免疫球蛋白(immunoglobulin,Ig)G、Ig A、Ig M、分化簇(cluster of differentiation,CD)3+、CD4+及CD4+/CD8+水平均明显高于治疗前,差异均有统计学意义(P<0.05)。结论在一般常规治疗基础上,孟鲁司特钠联合匹多莫德治疗RRTI患儿比单纯应用匹多莫德具有总有效率更高、症候改善更明显,并能更加有效改善肺功能及免疫功能,值得在临床推广使用。

ObjectiveTo investigate the effects of montelukast sodium combined with pidotimer on pulmonary function and immune function in children with recurrent respiratory tract infections （RRTI）. MethodsSubjects were selected from January 2015 to January 2016 in outpatient clinic of Navy General Hospital for 78 patients with RRTI. According to the type of treatment of children were divided into control group and observation group, 39 cases in each group. Two groups of patients were given pimodomu, atomization treatment and active antiinfection in general conventional treatment, the observation group was added oral montelukast sodium treatment for three months. After the end of treatment, the two groups of patients with total effective rate, clinical symptoms, lung function and immune function were compared. ResultsThe effective rate （94.87%） was significantly higher in the observation group than that in the control group （61.54%）, and the difference was statistically significant （P〈0.05）. The disappeared time of cough, fever and lung rales were shorter in the observation group than those in the control group, but the difference were not statistically significant （P〉0.05）; the levels of forced vital capacity （FVC）, forced expiratory volume in one second （FEV1）, FEV1/FVC, 50% peak expiratory flow and peak expiratory flow in the two groups were significantly higher than those before treatment （P〈0.05）, and the observation group was significantly higher than in the control group （P〈005）; the levels of serum immunoglobulin （Ig）G, lgA, IgM, CD3＋, CD4＋ and CD4＋/CD8＋ in the two groups were significantly higher than those before treatment （P〈0.05）. ConclusionOn the basis of general conventional treatment, montelukast sodium combined with pidotimer in children with RRTI has a higher efficiency and symptoms relieved, the symptoms improved more clearly, which is worth in clinical application.