射频消融治疗60岁以上肝细胞癌患者总生存率的meta分析

The overall survival rate of over 60 years old patients with hepatocellular carcinoma after receiving radiofrequency ablation: a meta analysis

目的探讨射频消融(RFA)对老年(>60岁)肝细胞癌(HCC)患者总生存率的影响,为老年HCC患者的治疗提供依据。方法系统收集2000-2016年研究RFA治疗老年与非老年HCC患者总生存率差异的回顾性队列研究,从中提取相关数据;按照NOS量表对纳入文献进行质量评价。结果共纳入12项回顾性队列研究,包括老年患者1 589例,非老年患者3 336例。Meta分析显示老年患者总生存率低于非老年患者[HR=0.850,95%CI(0.755,0.958),P=0.008];敏感性分析揭示两组总生存率的差异结果可靠,Egger检验显示无明显发表偏倚。结论老年HCC患者接受RFA治疗总生存率低于非老年患者。

Objective To investigate the effect of radiofrequency ablation （RFA） treatment on the overall survival rate in the aged patients （over 60 years old） with hepatocellular carcinoma （HCC）. Methods The retrospective cohort studies regarding to the difference in overall survival rate between aged HCC patients and non-aged HCC patients who were treated with RFA, which were published in the period from 2000 to 2016, were collected, from which the relevant data were extracted. The quality of enrolled studies was evaluated according to the NOS scale. Results A total of 12 retrospective cohort studies were enrolled in this study, including 1 589 aged patients and 3 336 non-aged patients. Meta analysis showed that the overall survival rate in aged HCC patients was lower than that in non-aged HCC patients （HR=0.850, 95% CI：0.755 and 0.958, P=0.008）. The sensitivity analysis revealed that the results of the difference in overall survival rate between the two groups were reliable. Egger＇s testing indicated that no significant publication bias existed. Conclusion In treating HCC with RFA, the overall survival rate of aged patients is lower than that of non-aged patients.