亲属供体粪菌移植缓解放射性肠炎病案报告

One Case Report of Alleviating Radioactive Enteritis by Fecal Microbiota Transplantation with Relative Donor

放疗普遍用于恶性肿瘤的治疗,然而,放疗经常导致多种或轻或重的副作用,严重降低患者生存质量。放射性肠炎是腹盆腔肿瘤经放疗后的常见并发症,发病率呈增加趋势。现有内科药物治疗不能有效根治,外科手术治疗存在较大风险。肠道菌群与人的健康和多种疾病密切相关,放射性肠炎存在肠道菌群紊乱。粪菌移植是起源于中医古方,近年来兴起的新疗法,对难辨梭状芽孢杆菌引起的肠病及炎症性肠病疗效显著。本文报道一位18年前因宫颈癌行放疗导致放射性肠炎的患者,经亲属供体粪菌移植症状获得显著缓解的案例,这是迄今第一例粪菌移植用于难治性放射性肠炎并取得良好疗效的报道。

Radiotherapy has been widely used as the medical treatment for patients with malignant tumors. However, a number of common, well-described side effects result from radiotherapy, which compromise the quality of life of the patients. Radiation enteritis（RE） is a frequent complication in patients who undergo pelvic irradiation, which has been increasingly diagnosed. Existing internal medicine therapy cann ot effectively solve the problem, while surgery has a big risk. Intestinal flora is closely related to people＇ s health and diseases and RE is suspected to be associated with intesti- nal flora disturbance. Fecal bacteria transplantation（FMT） originated from traditional Chinese medicine and is rising new therapies in recent years, which has remarkable curative effect for the clostridium bowel disease and inflammatory bowel disease. Here, we present a case of recurrent RE with radiation enteritis 18 years after radiotherapy for cervical carcinoma. FMT therapy with intestinal flora from her 18 years old son was applied and was successful in relieving the symptoms. To the best of our knowledge, this is the first case report of FMT in a patient with radiation enteritis.