肝移植术后新发糖尿病的研究进展

Research progress of new-onset diabetes mellitus after liver transplantation

肝移植是目前全世界公认的治疗终末期肝病最有效的方法，但肝移植术后新发糖尿病已成为移植术后严重的、常见的并发症，增加了感染、心血管疾病、移植物排斥、移植物功能不良等疾病的发生率、降低了患者生存率。现就肝移植术后新发糖尿病的流行病学、发病机制、危险因素和防治措施进行综述，以期为临床预防和治疗肝移植术后新发糖尿病提供指导。

Liver transplantation is an effective treatment for end-stage liver diseases, recognized around the world. However, new-onset diabetes mellitus after liver transplantation （NODAT） has become a common and serious complication after implantation, which increased the incidence of infections, cardiovascular diseases, graft rejection and graft dysfunction, so that the survival rate of patient was reduced. The epidemiology, pathogenic mechanisms, risk factors and prevention of NODAT are reviewed in the study to provide guidance for clinical prevention and treatment of NODAT.