摘要
神经突起导向因子netrins是层粘联蛋白家族的成员,最初被认为是轴突的引导分子。随后,人们发现netrins参与调节多种生理过程,包括胚胎形态发生、肿瘤发生、粘附以及最近的血管生成。netrin-1和netrin-4在内皮细胞中既有抗血管生成的作用,又有促进血管生成的作用。这些相反的结论似乎与内皮细胞的表现形式和结合的受体类型有关。
Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either proor antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype and seem also to depend on the receptor type to which netrins binds.
作者
丁丝露
李光
DING Si-lu, LI Guang(Department of Radiation Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China)
出处
《解剖科学进展》
2018年第2期197-200,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81402520)
关键词
抗血管生成
Netrins
netrins
内皮细胞
导向因子
神经突起
生理过程
形态发生
Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either proor antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype and seem also to depend on the receptor type to which netrins binds.
