极速脉搏波技术在评估体重指数与颈动脉弹性相关性中的价值

Value of ultrafast ultrasound imaging plus wave velocity in evaluating the correlation between body mass index and carotid arterial stiffness

目的:探讨利用极速脉搏波技术(uf PWV)评估体重指数(BMI)与颈动脉弹性相关性的价值。方法:收集我院体检人群277例,测量身高、体重、血压及血脂、血糖(GLU),并计算BMI,检测颈动脉内中膜厚度(IMT),再利用uf PWV测量颈动脉收缩早期脉搏波传导速度(BS)、收缩末期脉搏波传导速度(ES)。依据BMI将研究对象分为3组:超重组76例(151条颈动脉)、肥胖组22例(43条颈动脉)及正常体重组179例(357条颈动脉)。结果:(1)正常组与超重组比较,ES差异有统计学意义(P<0.001),BS、IMT差异均无统计学意义(P>0.05);肥胖组与正常组或超重组比较,BS、ES、IMT差异均有统计学意义(P<0.05)。(2)利用多元线性回归分析校正年龄、血压等混杂因素,将肥胖组与正常组或超重组进行两两比较,BS、ES、IMT差异仍有统计学意义(均P<0.05)。(3)BMI与BS、ES、IMT的相关性分析显示,ES的相关系数(0.403)明显大于BS、IMT。结论:uf PWV技术与IMT相比,在显示血管弹性与BMI的相关性上更敏感。uf PWV技术可作为定量评估动脉弹性及粥样硬化的新型有效手段。

Objective： To explore the value of ultra fast ultrasound imaging plus wave velocity（ uf PWV） in evaluation the correlation between body mass index（ BMI） and carotid arterial stiffness. Methods： A total of 277 subjects were enrolled in this study,the height,weight,blood pressure,blood lipid,blood glucose（ GLU） were measured,and BMI was calculated. The carotid intima-media thickness（ IMT） was detected and then the uf PWV technology was used to assess the beginning-systole pulse wave velocity（ BS） and end-systole pulse wave velocity（ ES）. According to BMI,the subjects were divided into three groups： 76 cases（ 151 carotid arteries） in the overweightgroup,22 cases（ 43 carotid arteries） in the obesity group and 179 cases（ 357 carotidarteries） in the normal group. Rseults：（ 1） The difference of ES between the normal group and the overweight group was statistically significant（ P〈0. 001）,the differences of BS and IMT between the normal group and the overweight group were not statistically significant（ P〈0. 05）. The differences of BS,ES and IMT between the obesity group and the normal group or the overweight group were statistically significant（ all P〈0. 05）.（ 2） By using multivariate linear regression analysis to control confounding factors,including age,blood pressure and so on,the differences of BS,ES and IMT between the obesity group and the normal group or the overweight group were still statistically significant（ P〈0. 05）.（ 3） The correlations between BMI and BS,ES,IMT were analyzed,the correlation coefficient of ES was larger than those of of BS or IMT. Conclusions： uf PWV technology is more sensitive in showing the correlation between vascular elasticity and BMI than IMT. It can be used as a new effective method for quantitative evaluation of arterial elasticity and atherosclerosis.