慢性肾脏病患者钙磷代谢紊乱及其治疗策略

Calcium/phosphate metabolism disorder of chronic kidney disease patients and its treatment strategies

钙磷代谢紊乱是慢性肾脏病(CKD)特别是透析患者常见的并发症之一,可导致各类肾性骨病,还可促进血管钙化,增加心血管事件的死亡风险,有效控制和管理钙磷代谢紊乱与CKD患者的长期预后密切相关。本文总结CKD患者钙磷代谢紊乱的发病情况、危害、监测频率、靶目标值及其治疗策略,从维持正常血钙、降低高血磷、控制异常甲状旁腺激素水平等方面简要综述钙磷代谢的管理策略。

Calcium/phosphate metabolism disorder is a common complication of chronic kidney disease（CKD）, especially for dialysis patients. It could cause various bone diseases and increase the risk of vascular calcification and cardiovascular events. Therefore, it is very important to control and manage calcium/phosphate metabolism disorder effectively. This paper describes the pathogenesis and clinical harm of calcium/phosphate metabolism disorder on CKD patients, and summarizes the control target and treatment strategies, including maintaining normal serum calcium, reducing elevated phosphate levels and controlling abnormal PTH levels.