不同剂量阿伐他汀联合阿司匹林治疗原发性高血压并动脉粥样硬化的临床研究

A Clinical Study on Different Doses of Atorvastatin and Aspirin in the Treatment of Essential Hypertension with Atherosclerosis

目的:探讨不同剂量阿托伐他汀联合阿司匹林治疗原发性高血压并动脉粥样硬化的临床疗效。方法:选取2015年1月-2016年12月在我院治疗的原发性高血压并动脉粥样硬化患者80例,随机分为对照组和实验组,每组40例。实验组给予口服高剂量阿托伐他汀(40 mg/d)联合阿司匹林肠溶片(100 mg/d)治疗,对照组给予口服高剂量阿托伐他汀(20 mg/d)联合阿司匹林肠溶片(100 mg/d)治疗,疗程均为3个月。观察和比较两组患者治疗前后的总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoproteincholesterol,HDL-C)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、收缩压(systolic blood pressure,SBP)、舒张血压(diastolic blood pressure,DBP)以及颈动脉斑块分级。结果:两组治疗后的SBP、DBP、血清TC、TG和LDL-C水平均较治疗前显著降低,血清HDL-C水平较治疗前明显升高,且实验组SBP、DBP、血清TC、TG和LDL-C水平均显著低于对照组(P<0.05),血清HDL-C水平明显高于对照组(P<0.05)。实验组颈动脉斑块0-Ⅰ级的比例显著高于对照组(P<0.05)。结论:口服高剂量阿托伐他汀(40 mg/d)联合阿司匹林肠溶片(100 mg/d)治疗原发性高血压并动脉粥样硬化较低剂量阿托伐他汀(20 mg/d)联合阿司匹林肠溶片(100 mg/d)疗效更好,可以有效降低血压,调节血脂并改善患者预后。

Objective： To explore the clinical efficacy of different doses of atorvastatin combined with aspirin in the treatment of primary hypertension with atherosclerosis. Methods： The clinical data of patients with essential hypertension treated by atorvastatin and aspirin in our hospital from January 2015 to December were randomly divided into the control group and the experimental group, 40 cases in each group. The experimental group was given oral high dose of atorvastatin（40 mg/d） combined with aspirin enteric-coated tablet（100 mg/d）, while the control group was given low dose of atorvastatin（20 mg/d） combined with aspirin enteric-coated tablet（100 mg/d）, the course of treatment was 3 months. The levels of total cholesterol（TC）, high-density lipoproteincholesterol（HDL-C）,triglyceride（TG）, low-density lipoprotein cholesterol（LDL-C）, systolic blood pressure（SBP）, diastolic blood pressure（DBP） and carotid plaque grade were observed and compared before and after the treatment between two groups. Results： After treatment, the levels of SBP,DBP, serum TC, TG and LDL-C in the two groups were significantly lower than those before treatment, the serum HDL-C levels were significantly higher than before treatment（P〈0.05）. The levels of SBP, DBP, serum TC, TG and LDL-C in the experimental group were significantly lower than those in the control group（P〈0.05）, serum HDL-C level was significantly higher than that in the control group（P〈0.05）. The proportion of carotid plaque 0-I in the experimental group was significantly higher than that of the control group（P〈0.05）.Conclusions： High dose of atorvastatin（40 mg/d） combined with aspirin enteric-coated tablets（100 mg/d） is more effective than low dose atorvastatin（20 mg/d） combined with aspirin enteric-coated tablets（100 mg/d） in the treatment of primary hypertension with atherosclerosis, it can reduce the blood pressure, regulate the blood lipids and improve the prognosis of patients.