老年肺癌患者化疗期间抑郁情况调查及相关因素分析

Investigation and Analysis on the Related Factors of Depression in Elderly Patients with Lung Cancer during Chemotherapy

目的:调查老年肺癌患者化疗期间抑郁情况及分析其相关因素。方法:选取2012年1月至2016年12月在我院化疗的老年肺癌患者300例,调查统计患者的基本信息资料,采用Zung氏自评抑郁量表(SDS)评价患者的抑郁情况,统计患者抑郁情况的调查结果,并采用Logistic回归分析影响老年肺癌患者抑郁的相关因素。结果:300例老年肺癌的患者当中,在化疗期间有抑郁者164例,占54.67%。其中59例是轻度抑郁,占35.98%;90例是中度抑郁,占54.88%;15例是重度抑郁,占9.15%。单因素分析显示,老年肺癌患者抑郁发生率与年龄、收入水平、TNM分期及有无癌症转移有关(均P<0.05),与性别、文化程度、癌症分型无关(P>0.05)。多因素Logistic回归分析显示影响老年肺癌患者抑郁的相关因素有年龄≥70岁、收入水平<3000元/月、TNM分期为Ⅲ~Ⅳ期以及癌症转移(P<0.05)。结论:老年肺癌患者在化疗期间较容易出现抑郁症状,临床上应加以重视,年龄≥70岁、收入水平<3000元/月、TNM分期为Ⅲ~Ⅳ期以及癌症转移是影响老年肺癌患者抑郁的相关因素,针对相关因素应尽早采取相应的干预措施,从而有利于改善患者的负性心理情绪。

Objective： To investigate the depression of elderly patients with lung cancer during chemotherapy and its related factors. Methods： A total of 300 elderly patients with lung cancer treated with chemotherapy in our hospital from January 2012 to December 2016 were selected. The basic information of the patients were investigated and statistics, and Zung＇s self rating depression scale was used in the evaluation of depression of patients. The evaluation results were collected, and the single factors and related factors of depression were statistically analyzed by logistic regression analysis. Results： Among the 300 cases of elderly patients with lung cancer, 164 patients were depressed during chemotherapy, accounting for 54.67%.59 cases among them were mild depression,accounting for 35.98%; 90 cases were moderate depression, accounting for 54.88%; 15 cases were severe depression, accounting for9.15%. The Single factor analysis showed that the incidence of depression in elderly patients with lung cancer was related to age, income level, TNM stage and cancer metastasis（all P〈0.05）, and was not related to gender, educational level and cancer type（P〈0.05）.Multivariate Logistic regression analysis showed that factors related to depression in elderly patients with lung cancer were age ≥70,income level3000 yuan/month, TNM stage Ⅲ～Ⅳ and cancer metastasis（P〈0.05）. Conclusion： Elderly patients with lung cancer are prone to depressive symptoms during chemotherapy, which should be paid attention to in clinic. Age≥70, income level3000 yuan/month, TNM stage Ⅲ～Ⅳ and cancer metastasis are the related factors of depression in elderly patients with lung cancer, and appropriate intervention measures should be taken as soon as possible for the related factors, in order to improve the negative emotions of patients.