超声检查联合MMP-2、MMP-9水平检测对甲状腺癌的诊断价值

Diagnostic Value of Ultrasonography Combined with MMP-2 and MMP-9 in Thyroid Carcinoma

目的:探讨超声检查联合基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)水平检测对甲状腺癌的诊断价值。方法:选取2014年6月-2016年6月我院收治的480例甲状腺结节患者作为研究对象,根据患者病情分为良性结节患者412例(良性结节组)和甲状腺癌患者68例(甲状腺癌组)。对所有患者进行超声检查与MMP-2、MMP-9水平检测,比较两组MMP-2、MMP-9水平,并比较超声检查与超声联合MMP-2、MMP-9水平检测对甲状腺癌的诊断价值。结果:甲状腺癌组MMP-2、MMP-9水平均显著高于良性结节组(P<0.05),且甲状腺癌组超声弹性图像评分多为3~4分,良性结节组则多为0~2分,两组超声弹性成像评分所占比例比较差异有统计学意义(P<0.05);超声联合MMP-2、MMP-9诊断良性甲状腺结节的阴性率和甲状腺癌的阳性率均高于超声诊断,差异有统计学意义(P<0.05);超声联合MMP-2、MMP-9的灵敏性、特异性、准确性分别为89.7%、85.2%、85.8%,均显著高于超声诊断的76.5%、68.7%、69.8%,差异有统计学意义(P<0.05)。结论:超声检查联合MMP-2、MMP-9水平检测能够有效鉴别甲状腺癌,其灵敏性、特异性、准确性均较高,值得在临床上推广。

Objective： To investigate the diagnostic value of ultrasonography combined with matrix metalloproteinase-2（MMP-2）and matrix metalloproteinase-9（MMP-9） in thyroid carcinoma. Methods： 480 patients with thyroid nodules who were treated in our hospital from June 2014 to June 2016 were selected as the subjects.They were divided into 412 cases of patients with benign nodules（benign nodules group） and 68 cases of patients with thyroid cancer（thyroid cancer group） according to the condition of patients. All patients were examined by ultrasonography and MMP-2, MMP-9 level detection, compared the levels of MMP-2, MMP-9 in two groups,and compared the diagnostic value between ultrasound and ultrasound combined with MMP-2, MMP-9 level detection in the thyroid carcinoma. Results： The levels of MMP-2 and MMP-9 in thyroid cancer group were significantly higher than those in benign nodules group（P〈0.05）. The ultrasound elastography score of thyroid cancer group was 3～4, and the benign nodules group was 0～2, the difference between the two groups was statistically significant（P〈0.05）; The negative rate of ultrasound combined with MMP-2 and MMP-9 in the diagnosis of benign thyroid nodules and the positive rate of thyroid cancer were higher than those of ultrasound, the differences were statistically significant（P〈0.05）; The sensitivity, specificity and accuracy of ultrasound combined with MMP-2 and MMP-9 were 89.7%, 85.2%, and 85.8% respectively, which were significantly higher than those of ultrasonic diagnosis of 76.5%, 68.7%,69.8%, the differences were statistically significant（P〈0.05）. Conclusion： Ultrasonography combine with MMP-2 and MMP-9 level detection can effectively identify thyroid cancer, the sensitivity, specificity and accuracy are higher, which is worthy of clinical promotion.