奥美拉唑联合柴胡疏肝散对胃溃疡患者血清NF-κB及IL-8表达的影响

Effect of Omeprazole Combined with Chaihu Shugan Powder on the Serum NF-κB and IL-8 Expressions of Patients with Gastric Ulcer

目的:研究奥美拉唑联合柴胡疏肝散治疗胃溃疡(Gastric ulcer,GU)的疗效及对血清核因子-κB(NF-κB)、白细胞介素-8(IL-8)表达的影响。方法:研究对象选取我院2015年10月到2016年10月收治的GU患者98例,采用随机数字法将其分为对照组和观察组,每组49例。对照组患者口服奥美拉唑治疗,在此基础上,观察组患者口服柴胡疏肝散治疗。比较两组患者的治疗总有效率、复发率及幽门螺旋杆菌(Helicobacter pylori,Hp)清除率、不良反应发生率及治疗前后的血清IL-8、NF-κB表达的变化。结果:治疗后,观察组的治疗总有效率(93.87%)明显高于对照组(67.64%)(P=0.00),血清IL-8和NF-κB水平均明显低于对照组(P<0.01),复发率明显低于对照组(P<0.05),Hp根除率明显高于对照组(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论:奥美拉唑联合柴胡疏肝散治疗GU的临床疗效显著优于奥美拉唑单药治疗,能促进Hp根除,有效抑制炎症反应,降低疾病复发率,且治疗安全性较高。

Objective： To study the clinical efficacy of omeprazole combined with Chaihu Shugan Powder in the treatment of gastric ulcer（GU） and its effect on the serum nuclear factor-κB（NF-κB） and interleukin-8（IL-8） levels. Methods： A total of 98 cases of patients with GU were enrolled in our hospital from October 2015 to October 2016. The patients were divided into the control group and the observation group by random number method. The patients in the control group were treated with oral omeprazole, while the patients in the observation group were treated with Chaihu Shugan Powder based on the control group. The recurrence rate and the clearance rate of Helicobacter pylori（Hp）, the incidence of adverse reactions and the changes of serum IL-8 and NF-κB levels before and after treatment were compared between the two groups. Results： After treatment, the total effective rate（93.87%） of observation group was significantly higher than that of the control group（67.64%）（P=0.00）, and the serum levels of IL-8 and NF-κB were significantly lower than those in the control group（P〈0.05）. The incidence of Hp eradication was significantly higher than that of the control group（P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P〈0.05）, and the recurrence rate was significantly lower in the observation group than that of the control group（P〈0.05）. Conclusion： Omeprazole combined with Chaihu Shugan Powder is significantly better than omeprazole monotherapy in the treatment of GU, which can promote the eradication of Hp,inhibit the inflammatory reaction, reduce the recurrence rate and improve the safety of treatment.