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致热适应因子是一种生物活性肽 被引量:4

HEAT ACCLIMATO-INDUCING FACTOR IS A BIOACTIVE PEPTIDE
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摘要 已证明家兔热适应之后脑脊液中存在着具有降温活性的物质。本研究对此物质进行了氨基酸分析,发现其中主要成分为甘氯酸、酪氨酸、丙氨酸、苯丙氨酸等。经用链霉蛋白酶酶解之后,失去降温活性,证实了该物质是一种小分子肽。 Previous work showed that a factor reducing body temperature appeared in the cerebrospinal fluid of rabbit acclimatized in artificial hot chamber. The factor is named as heat acclimato-inducing factor (HAI F). In this study HAIF was identified to be peptide in nature. After hydrolysis of HAIF with 6mol/L HC1 at 110℃ for 24 hours, analysis of amino acids of HAIF showed that it contained Gly, Glu, Tyr, Ala, Phe and a little Asp. Bioactive assay showed that after cleaving by pronase the temperature-reducing effect of HAIF disappeared. It is, therefore, considered that HAIF is a bioactive peptide consisting of the above amino acids with a molecular weight of 1 000-2 000 and that its bioactivity depends completely on the peptide.
出处 《中国应用生理学杂志》 CAS CSCD 1991年第1期36-38,共3页 Chinese Journal of Applied Physiology
关键词 致热适应因子 热适应 氨基酸分析 bioactive peptide hot environment analysis of amino acids intracerebroventricular microinjection.
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  • 1易庆成,陆大贤,吴时祥,邹冈.针刺镇痛和吗啡镇痛过程中脑内~3H-5-羟色胺释放的研究[J]中国科学,1977(01).
  • 2脑内某些神经介质在指针镇痛中的作用[J]中国科学,1974(01).

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