益气活血法联合尤瑞克林治疗急性脑梗死对S-100β蛋白的影响及临床疗效观察

Observation on effect of Yiqi Huoxue method combined with urinary kallindinogenase on S-100β protein in the treatment of acute cerebral infarction and its clinical efficacy

目的探讨益气活血法联合尤瑞克林治疗急性脑梗死的疗效,以及对S-100β蛋白的影响。方法 74例急性脑梗死患者,根据治疗方法的不同分为对照A组(23例)、对照B组(25例)和治疗组(26例)。对照A组采用一般治疗,对照B组在对照A组基础上联合尤瑞克林治疗,治疗组在对照B组基础上加用益气活血法(步长脑心通胶囊)治疗。观察比较三组患者治疗效果及治疗前、治疗后7、14 d的S-100β蛋白水平。结果对照A组治疗总有效率为69.57%,对照B组为80.00%,治疗组为96.15%,比较差异有统计学意义(P<0.05)。治疗前,三组患者S-100β蛋白水平比较,差异无统计学意义(P>0.05);治疗后7、14 d,治疗组S-100β蛋白水平均明显低于对照A组、对照B组,差异有统计学意义(P<0.05)。结论尤瑞克林联合益气活血法可降低急性脑梗死患者S-100β蛋白水平,具有神经功能保护作用,可改善患者预后,值得临床推广。

Objective To discuss the efficacy of Yiqi Huoxue method combined with urinary kallindinogenase in the treatment of acute cerebral infarction and its effect on S-100β protein. Methods A total of 74 acute cerebral infarction patients were divided by different treatment methods into control group A（23 cases）, control group B（25 cases） and treatment group（26 cases）. Control group A received general therapy, control group B received urinary kallindinogenase on the basis of control group A, and treatment group received Yiqi Huoxue method（Buchang Naoxintong capsules） on the basis of control group B. The treatment effect and S-100β protein level before treatment, 7 and 14 d after treatment between the two groups was observed and compared. Results Control group A had total treatment effective rate as 69.57%, which was 80.00% in control group B, and 96.15% in treatment group. Their difference was statistically significant（P〈0.05）. Before treatment, three groups had no statistically significant difference in S-100β protein level（P〉0.05）. After 7 and 14 d of treatment, the treatment group had obviously lower S-100β protein level than control group A and control group B, and the difference was statistically significant（P〈0.05）. Conclusion Combination of urinary kallindinogenase and Yiqi Huoxue method can reduce the level of S-100 β protein in patients with acute cerebral infarction and it shows protective effect for nerve function. It can improve the prognosis of patients and is worthy of clinical promotion.