不同剂量阿托伐他汀对不稳定型心绞痛患者C-反应蛋白的影响

Effects of atorvastatin on C-reactive protein in patients with unstable angina

目的探讨不同剂量阿托伐他汀对不稳定型心绞痛患者C-反应蛋白的影响。方法选取不稳定型心绞痛患者80例,将其随机分为高剂量组与低剂量组,每组40例。高剂量组患者采用阿托伐他汀治疗,低剂量组患者采用基本药物治疗。比较两组治疗有效率、患者满意率,及阿托伐他汀对不稳定型心绞痛患者C-反应蛋白的影响。结果高剂量组有效率(97.5%)高于低剂量组(77.5%),差异有统计学意义(P<0.05)。治疗后,高剂量组C-反应蛋白浓度为(8.24±1.31)mg/L,低剂量组为(10.62±1.22)mg/L,两组比较差异有统计学意义(P<0.05)。高剂量组满意率(90%)高于低剂量组为(60%),差异有统计学意义(P<0.05)。结论高剂量阿托伐他汀可以显著降低不稳定型心绞痛患者C-反应蛋白水平,并提高治疗有效率和患者满意度。

Objective To investigate the effects of atorvastatin on C-reactive protein in patients with unstable angina. Methods Eighty patients with unstable angina pectoris were selected and randomly divided into three groups： large dose group and small dose group,with 40 cases in each group. The effects of atorvastatin on patients with unstable angina pectoris C-reaction protein were compared.Results The effective rate of the patients in large dose group（ 97. 5%） was higher than those of the small dose group（ P〈0. 05）; the concentration of C-reactive protein after treatment in large dose group and small dose group respectively were（ 8. 24 ± 1. 31） mg/L and（ 10. 62 ± 1. 22） mg/L; the curative effect and degree of satisfaction in the large dose group were much higher than those of the small dose group（ P〈0. 05）. Conclusions Large-dose atorvastatin can significantly decrease the concentration of C-reactive protein,effective rate and the degree of satisfaction of patients with unstable angina.