不同促排卵方案在排卵障碍性不孕患者中的应用及安全性观察

Application and safety of different regimens of ovarian stimulation in patents with dysfunctional ovulatory sterility

目的观察不同促排卵方案在排卵障碍性不孕患者中的应用效果及安全性。方法选取排卵障碍性不孕患者120例，根据治疗方法分为A、B、C组，每组40例。A组单用克罗米芬治疗，B组单用来曲唑治疗，C组在A组基础上加用尿促性素。观察比较三组排卵情况、治疗周期及卵泡成熟情况。结果A、C两组完成周期少，且周期内排卵率高于B组，差异有统计学意义（P〈0．05）；人绒毛膜促性腺激素（HCG）日c组成熟卵泡数量及子宫内膜厚度均显著高于A、B两组，差异有统计学意义（P〈0．05）；三组治疗期间均无卵巢过度刺激综合征（OHSS）发生；C组雌二醇（E2）水平高于A、B两组，差异有统计学意叉（P〈0．05）；C组临床妊娠率高于A、B两组，平均用药周期少于A、B两组，差异有统计学意义（P〈0．05）。结论克罗米芬与尿促性素联合用于排卵障碍性不孕患者促排卵治疗，促排卵效果好，患者治疗周期短，正常妊娠率高，患者治疗期间卵巢过度刺激综合征发生少，安全性高。

Objective To observe the application and safety of different regimens of ovarian stimulation in patients with dysfunctional ovulatory sterility. Methods A total of 120 patients with dysfunctional ovulatory sterility were divided into group A, B, C by treatment methods, with 40 cases in each group. Group A only received elomiphene, group B only received letrozole, while group C was treated with menotrophin based on the treatment of group A. The ovulation, treatment cycle, follicle maturity were observed and compared among the three groups. Results The execution cycles of group A, C were less, and the ovulation rates were higher compared with group B （ P 〈 0. 05 ） ; the number of mature follicle and thickness of endometrium in human chorionie gonadotropin （HCG） day of group C were significantly higher than those of group A and B （P 〈 0. 05 ） ; there was no ovarian hyperstimulation syndrome （OHSS） in the three groups during treatment ; the level of estradiol （E2） in group C was higher than that in group A and B （ P 〈 0. 05 ） ; the clinical pregnancy rate in group C was higher than that in group A and B, and the average medication cycle was less than that in group A and B （P 〈 0.05 ）. Conclusions Clomiphene combined with menotrophin in the treatment of dysfunctional ovulatory sterility has good effects on ovarian stimulation, which has advantages of short treatment cycle, high normal pregnancy rate, less OHSS during treatment and high safety.