血胆红素、hs—CRP与2型糖尿病肾病的相关性分析

Correlation between serum bilirubin, hs-CRP find type 2 diabetic nephropathy

目的探讨血胆红素水平、超敏C-反应蛋白（hs—CRP）与2型糖尿病肾病的关系。方法762例2型糖尿病患者依据尿微量白蛋白／尿肌酐（ACR）水平分为正常白蛋白尿组（465例）、微量白蛋白尿组（198例）和临床白蛋白尿组（99例）。所有的患者均详细收集临床资料并测定血糖、血脂、血清hs—CRP、胆红素等生化指标。结果正常白蛋白尿组、微量白蛋白尿组及临床蛋白尿组hs—CRP水平逐渐升高，而血胆红素水平逐渐下降，差异均有统计学意义（P均〈0．05）。hs—CRP与血胆红素是ACR的独立危险因素。结论随着糖尿病肾病的进展，hs—CRP水平逐渐升高，而血胆红素水平逐渐下降，提示二者可能是糖尿病肾病发生、发展的重要危险因素。

Objective To study the correlation between serum bilirubin, high-sensitive C-reactive protein （hs-CRP） and type 2 diabetic nephropathy. Methods A total of 762 patients with type 2 diabetic nephropathy were collected and divided into three groups according to urine microalbumin/creati- nine ratio （ACR） value ： normal albuminuria group （ n = 465）, microalbuminuria group （ n = 198） and clinical albuminuria group （n = 99）. The clinical data were collected, and blood serum hs-CRP, bilirubin and other biochemical indexes were measured. Results glucose, blood lipid, The hs-CRP increased gradually, while the level of serum bilirubin decreased gradually in the three groups, the differences were significant （all P 〈 0. 05 ）. The Logistic muhic-factor regression analysis showed that both hs-CRP and serum bilirubin were independent risk factors of ACR. Conclusions Increased hs-CRP and decreased serum bilirubin are related to the the progress of the diabetic nephropathy. It suggests that hs-CRP and bilirubin may be important risk factors for development of diabetic nephropathy.