阿奇霉素联合辛伐他汀治疗慢阻肺合并肺动脉高压的效果探讨

Effect of azithromycin combined with simvastatin for COPD accompanying pulmonary hypertension

目的:探讨用阿奇霉素联合辛伐他汀治疗慢性阻塞性肺疾病(简称慢阻肺)合并肺动脉高压的效果。方法:将2016年1月至2017年6月期间四川省成都市龙泉驿区第二人民医院收治的88例慢阻肺合并肺动脉高压患者作为研究对象。将这些研究对象随机分为对照组(n=44)和治疗组(n=44)。为对照组患者使用辛伐他汀分散片进行治疗。为治疗组患者使用阿奇霉素联合辛伐他汀分散片进行治疗。然后,比较两组患者的血氧分压、动脉血二氧化碳分压、肺动脉压、一秒钟用力呼气量及用力肺活量。结果:接受治疗后,治疗组患者的血氧分压及肺动脉压均低于对照组患者,其动脉血二氧化碳分压高于对照组患者,其一秒钟用力呼气量及用力肺活量均大于对照组患者(P<0.05)。结论:用阿奇霉素联合辛伐他汀治疗慢阻肺合并肺动脉高压的效果显著。

Objective：To study effect of azithromycin combined with simvastatin for chronic obstructive pulmonary disease（COPD） accompanying pulmonary hypertension.Methods：Select 88 cases of the patients with COPD accompanying pulmonary hypertension received by The Second People＇s Hospital of Longquanyi District during January 2016 to June 2017 for research object.Divide the cases to control group（n=44）and experimental group（n=44）.Treat control group with simvastatin dispersible tablets,treat experimental group with azithromycin combined with simvastatin dispersible tablets.Then compare Pa O2,Pa CO2,pulmonary artery pressure,FEV1,FVC of 2 groups.Results：After treatment,the Pa O2 and pulmonary artery pressure of experimental group are lower than that in control group,Pa CO2 of experimental group is higher than that in control group,the FEV1 and FVC of experimental group are larger than that in control group（P〈0.05）.Conclusion：The effect of azithromycin combined with simvastatin for COPD accompanying pulmonary hypertension is good.