昼夜节律紊乱与胰岛β细胞缺陷关系的研究进展

Research Progress of Association between Circadian Rhythm Disruption and Beta-cell Failure

生物的许多生命现象多有其固有的周期,呈现出昼夜节律、月节律和年节律性。昼夜节律是人类生命活动最普遍存在的一种节律形式,但这种节律周期可能被现代许多生活方式所破坏。人群流行病学和动物实验研究表明昼夜节律的紊乱与2型糖尿病的发病危险相关,但其机制尚未完全阐明。胰岛β细胞缺陷是2型糖尿病发生发展的必要机制,而昼夜节律紊乱与胰岛β细胞缺陷有一定关联。本文结合最新研究进展阐述昼夜节律紊乱与胰岛β细胞缺陷的相关性及其可能机制。

Many biological phenomena of living organisms have their inherent cycles, characterized by circadian rhythm, monthly rhythm and Annual rhythm. The circadian rhythm system widespread existed in humans, however, modern lifestyles maybe contribute to disruption of circadian rhythms. Epidemiological and animal studies show that circadian rhythm disorder is associated with the augment of type 2 diabetes susceptibility, though the mechanism has not been known. Beta-cell failure is essential for development of T2DM, and beta-cell failure is related to circadian disruption. This article elaborates the correlation of beta-cell failure with circadian disruption on the basis of recent studies, and investigate the potential mechanisms.