针刺联合安肠散穴位贴敷治疗腹泻型肠易激综合征临床研究

Observation of curative effect of acupuncture combined with Anchang powder acupoint application in the treatment of irritable bowel syndrome with diarrhea

目的 评价针刺联合安肠散穴位贴敷治疗腹泻型肠易激综合征（irritable bowel syndrome-diarrhea, IBS-D）的疗效。方法 将符合入选标准的100例IBS-D患者采用随机数字表法分为2组，每组50例。对照组口服马来酸曲美布汀，治疗组采用针刺联合安肠散穴位贴敷。2组均连续治疗4周，随访6个月。采用临床症状评分评估症状的严重程度，采用生活质量量表（Quality of Life, QOL）评价患者的生活质量，记录随访期间的复发率，评价临床疗效。结果 治疗组总有效率为92.0%（46/50）、对照组为68.0%（34/50），2组比较差异有统计学意义（χ2＝9.000，P＝0.003）。治疗后，治疗组临床症状积分[（1.89±0.95）分比（4.02±1.13）分，t＝10.202]低于对照组、QOL评分[（34.15±6.75）分比（28.47±5.01）分，t＝4.803]高于对照组（P＜0.01）。随访期间，对照组复发率为64.7%（11/17）、治疗组为24.1%（7/29），2组比较差异有统计学意义（χ2＝7.405，P＝0.007）。结论 针刺联合安肠散穴位贴敷可明显改善IBS-D患者的临床症状和生活质量，降低复发率。

Objective To study the effects of acupuncture combined with Anchang powder acupoint application in the treatment of irritable bowel syndrome with diarrhea. Methods A total of 100 patients with irritable bowel syndrome with diarrhea in our hospital from July 2014 to July 2016 were enrolled.The subjects were randomly divided into the control group （n=50） and the treatment group （n=50）. The control group were treated with trimebutine, while the treatment group were treated with acupuncture combined with Anchang powder acupoint application. The two groups were treated for 4 weeks. The clinical effects of the two groups after treatment were compared. The clinical symptom scale was used to evaluate the clinical symptoms, and the quality of life was evaluated by the quality of life scale （QOL） The recurrence rate after half a year heal of the two groups were compared. Results The total efficacy rate of the treatment group was 92.0% （46/50）, significantly higher than 68.0% （34/50） of the control group （χ2=9.000, P=0.003）. After treatment, the clinical symptom integral （1.89 ± 0.95 vs. 4.02 ± 1.13, t=10.202） of the treatment group were significantly lower than the control group （P〈0.05）. After treatment, the quality of life rating scores （34.15 ± 6.75 vs. 28.47 ± 5.01, t=4.803） of the treatment group were significantly higher than the control group （P〈0.01）. Half a year after treatment, the recurrence rate of the treatment group was 24.1% （7/29）, significantly lower than 64.7% （11/17） of the control group （χ2=7.405, P=0.007）. There was no significant difference of the two groups during the treatment. Conclusions Acupuncture combined with Anchang powder acupoint application showed a good efficacy for the patients with irritable bowel syndrome with diarrhea. And the treatment showed the low incidence of adverse reactions and low recurrence rate, can mprove the clinical symptom and quality of life.