免疫细胞在胰腺癌发生发展中的作用

Roles of Immune Cells in Development of Pancreatic Cancer

胰腺癌是最常见的消化系统恶性肿瘤之一,胰腺癌早期诊断率非常低,患者确诊时往往已进入癌症晚期,而且胰腺癌患者的预后较差。另外,胰腺癌对传统的放射治疗和化学药物治疗均不敏感。因此,为了提高临床胰腺癌的治疗效果,迫切地需要发现新的治疗策略,如免疫治疗法。胰腺炎是胰腺癌最重要的危险因子。本篇综述将重点阐述炎症相关的免疫细胞如肿瘤相关单核吞噬细胞（TAM）、髓系抑制性细胞（MDSC）、调节性T细胞（Treg）、CTL和γδT细胞等在介导炎症反应与胰腺癌发生发展中的相互作用,为胰腺癌免疫治疗提供理论依据。

Pancreatic cancer is an aggressive malignancy that is frequently diagnosed at advanced stage with poor prognosis. Moreover,it is often unresponsive to conventional radiation and chemotherapy. Therefore,novel therapeutic strategies,such as immunological approaches,are urgently needed to improve the clinical outcome of pancreatic cancer patients. Pancreatitis is the most important risk factor for pancreatic cancer. This review focuses on inflammation related im-mune cells such as tumor-associated macrophages（TAM）,myeloid-derived suppressor cells（MDSC）,regulatory T cell（Treg）,CTL and γδT cells in mediating inflammation and its roles in the development of pancreatic cancer,which may provide theoretical basis for immunotherapy of pancreatic cancer.