雌激素与椎动脉型颈椎病相关性研究

The Correlation between Estrogen and Cervical Spondylopathy of Vertebral Artery

目的:探讨雌激素与椎动脉型颈椎病的相关性。方法:测定椎动脉型颈椎病患者血清雌激素(E_2)、瘦素(LEP)、白介素-6(IL-6)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)表达水平,分析雌激素与这些指标的相关性。结果:与对照组相比,颈椎病组E2、HDL水平显著降低(P<0.05),LEP、IL-6、TC、TG及LDL水平显著升高(P<0.05、P<0.01);且E2水平与LEP、IL-6、TC、TG及LDL水平呈负相关,与HDL呈正相关。结论:雌激素可能是椎动脉型颈椎病的重要保护因素之一。

Objective： To investigate the correlation between estrogen and cervical spondylopathy of vertebral artery. Methods： The expression levels of serum estrogen （E2）, leptin （LEP）, interleukin-6 （IL-6）, total cholesterol （TC）, triglycerides （TG）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） in patients with cervical spondylopathy of vertebral artery were detected to analyze the correlation between estrogen and the other indexes. Results： Compared with control group, the levels of E2 and HDL of cervical spondylosis group were significantly decreased （P〈0.05） while LEP, IL-6, TC, TG and LDL were significantly increased （P〈0.05, P〈0.01）; and the level of E2 was negatively correlated with the levels of LEP, IL-6, TC, TG and LDL while positively with HDL. Conclusion： Estrogen may be one of the important protective factors of cervical spondylopathy of vertebral artery.