壬基酚每日可耐受摄入量建议值的探讨

Discussion of tolerable daily intake for nonylphenol

目的对壬基酚的健康指导值进行探讨,为进一步评估壬基酚暴露对人类健康的风险奠定基础。方法本研究采用系统综述的原则与方法,在广泛检索现有壬基酚毒理学数据的基础上,筛选高质量的文献纳入研究数据库,经全面评估后选择适宜的临界效应,结合不确定性分析确定壬基酚的每日可耐受摄入量。结果经过文献收集和筛选,最终选用以一项较高质量多代生殖毒性研究中观察到的肾脏毒性为敏感指标,以其观察到有害作用的最低水平(lowest observable adverse effect level,LOAEL)为外推起始点,使用LOAEL-不确定系数法进行推算。结论壬基酚的每日可耐受摄入量为0.025 mg/kg BW。

Objective The aim of this study was to derive the health-based guidance values for nonylphenol（ NP）,which would lay the foundation for further evaluating the human health risk of nonylphenol. Methods According to the principles and method ology of risk assessment and systematic review,using a weight of evidence approach,high-quality studies was selected into database by systematically reviewing of toxicology data and uncertainty factors. Results After comprehensive assessment,the toxicity information is provided by a high quality multi-generation reproductive toxicity study and lowest observable adverse effect level（ LOAEL） method was choen. Renal toxicity was selected as the critical effect,and a LOAEL was considered as the point of departure for extrapolation. Conclusion The tolerable daily intake value of0. 025 mg/kg BW was recommended as the final health-based guidance value for NP.