多西环素对全氟异丁烯吸入性急性肺损伤大鼠的防治效果

目的观察多西环素（DOX）对大鼠全氟异丁烯（PFIB）吸入性急性肺损伤（ALI）的防治效果，为寻找防治PFIB中毒的有效药物提供理论根据。方法用自制的大鼠全身暴露动态吸入染毒系统构建大鼠PFIB吸入性ALI模型。观察D0x治疗组与中毒对照组肺系数以及支气管肺灌洗液（BALF）中蛋白及磷脂含量变化。结果DOX在PFIB染毒后1h腹腔注射可以明显减轻肺损伤，显著减少BALF中蛋白磷脂含量。结论Dox治疗PFIB吸入性ALI可以减轻PFIB染毒大鼠的肺损伤，减少了肺泡腔内液体渗出，减轻了肺间质瘀血水肿的程度。

Objective To observe the therapeutic effect of doxycycline （ DOX ） on acute lung injury （ ALl ） induced by perfluoroisobutylene （ PFIB ） -inhaled in the rats and to provide theoretical basis for treatment of ALI induced by PFIB. Methods The Wistar rats were exposed to gaseous PFIB in a whole body exposure system, the lung coefficient, protein content and phosphatide content of bronchial veolar lavage fluid （ BALF ） in PFIB- inhaled rats were measured. Results DOX could significantly alleviate the ALI when PFIB was inhaled 1 hour later. Conclusion DOX can reduce the alveolar liquid leakage and the degree of pulmonary interstitial edema.