还原型谷胱甘肽联合雅莎尔优白素治疗黄褐斑的临床效果

目的探讨还原型谷胱甘肽联合雅莎尔优白素治疗黄褐斑的临床效果。方法选择2015年3月至2016年3月进行黄褐宽治疗的患者120例，按照治疗方式分为对照组和观察组，每组各60例。对照组利用自制中药祛斑面膜和还原型谷胱甘肽进行治疗，观察组利用自制中药祛斑面膜，还原型谷胱甘肽和雅莎尔优白素的联合干预方法，对治疗的效果进行对比。结果对照组的治疗有效率为91．67％，观察组的治疗有效率为100．00％，两组数据差异具有统计学意义（P〈0．05），观察组治疗有效率显著高于对照组，两组治疗效果差异也具有统计学意义（P〈0．05），观察组的治疗效果显著优于对照组，对照组共发生5例不良反应，观察组也发生5例不良反应，两组患者各种不良反应发生率的数据差异均不具有统计学意义（P〉0．05），所有不良反应未经特殊处理，1-2周后消失，两组患者手术效果满意度比较，差异具有统计学意义（P〈0．05），观察组显著优于对照组。结论利用还原型谷胱甘肽联合雅莎尔优白素对黄褐斑进行治疗，可以提高治疗效果和患者满意度，而且并未增加不良反应发生概率，值得在临床范围内推广使用。

Objective To investigate the clinical effect of g!utathione combined with YaShaer whitening essence in treating chloasma. Methods 120 cases ofchloasma treated patients in our hospital department of Dermatology form March 2015 to March 2016 were enrolled in the study and divided into control group and observation group according to the treatment of the patients, 60 patients in each group, the self-made traditional Chinese medicine freckle mask and glutathione treamaent was used, patients in the observation group were given the self-made traditional Chinese medicine freckle mask, was also a joint intervention prototype YaShaer glutathione and whitening essence method, then the treatment effect was compared. Results The effective rate of treatment group was 91.67%, the effective rate of treatment group was 100%, statisticany significant differences between the two groups of data （P〈0.05） , the effective rate of the observation group was significandy higher than the control group, the two groups of treatment effect, the data differences were statistically significant （P〈0.05） . The treatment effect of the observation group was significantly better than the control group, the control group with 5 cases of adverse reactions, the observation group had 5 cases of adverse reactions, two groups of patients with adverse reaction rate between the data were not statistically significant （ P〉0.05 ） , all adverse reactions without special treatment, one to two weeks after the disappearance the satisfaction of patients, the effect of the two groups of data were compared statistically significant difference （ P〈0.05 ） , the observation group was significantly better than the control group. Conclusion The use of reduced glutathione combined with YaShaer whitening essence on chloasma treatment, can improve the curative effect and patient satisfaction, but do not increase the probability of occurrence of adverse reactions, worthy of promotion in clinical use range.