地红霉素在轻度支气管哮喘合并吸烟患者中的疗效观察

目的观察地红霉素在支气管哮喘吸烟患者中的疗效。方法选取支气管哮喘病情分级1～2级并当前吸烟者40例，随机分为两组，对照组（予以布地奈德即普米克都保可粉剂常规吸入治疗）、观察组（地红霉素组，予以普米克都保吸入基础上加用地红霉素治疗）。连用2个月后，分别观察用药前后两组患者肺功能第1秒用力呼气容积（FEV1）、用力呼气峰值流速（PEF）、哮喘控制测试评分（ACT）。结果轻度支气管哮喘合并吸烟患者常规经吸入糖皮质激素治疗2月后，ACT评分及肺功能检测FEV1、PEF未见明显改善。而观察组加入地红霉素0．25g口服使用后，治疗前后ACT评分及肺功能检测值FEV1、PEF均有不同程度改善，差异均具有统计学意义（P〈0．05）。结论对于轻度支气管哮喘合并吸烟患者，常规吸入糖皮质激素控制哮喘，效果不佳，小剂量大环内酯类抗生素地红霉素联合吸入糖皮质激素能够改善患者ACT评分及肺功能FEV1和PEF值。

Objective To evaluate the effect of dirithromycin in the treatment of mild smoking asthma. Methods Selection of bronchial asthma grading 1~2 level and current smokers in 40 cases, were randomly divided into two groups, control group （ treated with budesonide powder conventional inhalation therapy ） and observation group （ erythromycin group, be budesonide powder plus erythromycin therapy ） , for 2 months respectively, two groups of patients before and after lung function forced expiratory volume in one second （FEV1） , forced expiratory peak flow velocity （ PEF ） , asthma control test score （ ACT score ） were observed. Results After inhaled corticosteroid treatment in patients with mild bronchial asthma and smoking, the ACT score and lung function test FEV1 and PEF were not significantly improved after February. After the oral administration of daunorubicin was 0.25g in the observation group, the ACT score and lung function test value FEV1 and PEF were improved in different degrees before and after treatment, the differences were statistically significant （ P〈0.05 ） . Conclusion Routine inhalation of glucocorticoid is no effective in mild smoking asthma, low dose ofdirithromycin combined with inhaled glucocorticoid can improve the values of ACT, FEV1 and PEF.