液晶纳米粒作为药物载体的研究进展

Research Progress of Liquid Crystalline Nanoparticles as Drug Delivery System

液晶纳米粒是由一定浓度的两亲性脂质在水中自组装分散形成的纳米粒,具有生物相容性高、生物黏附性好、载药量大等优点,其独特内部结构能够包封不同性质的药物,适合多种给药途径。液晶纳米粒作为一种新型药物载体在药物递送方面显示出广阔的应用前景。笔者对液晶纳米粒的形成,制备工艺,表征及其作为载药体的应用予以归纳和总结,为液晶纳米粒的进一步研究提供参考。

Liquid crystalline nanoparticles are composed of a certain concentration of amphiphilic lipid self-assembly in water. The attractiveness of this formulation is linked to the nanostructural versatility, eompatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Liq- uid crystalline nanoparticles, as a novel drug delivery system, have great promise in drug delivery. The carrier materials, preparation methods, characterization and applications of liquid crystalline nanoparticles were reviewed based on relevant articles published in re- cent years to provide reference for further study of liquid crystal nanoparticles.