摘要
烷化剂类抗癌药物可攻击细胞DNA分子众多部位,产生一系列DNA加合物,影响DNA复制和转录等过程,从而诱导细胞变异或凋亡。O6-烷基鸟嘌呤-DNA烷基转移酶（O6-alkylguanine-DNA alkyltransferase,AGT）是哺乳动物体内普遍存在的一种DNA修复蛋白酶,可使受损DNA得以修复,导致肿瘤细胞对化疗药物产生耐药性,降低肿瘤化疗的效果。就近年来有关DNA烷化损伤、AGT介导的肿瘤细胞的耐药性以及AGT抑制剂的应用研究进展进行综述。
Anticancer alkylating agents are able to attack some points of DNA in the cells and produce different types of DNA adducts,which affect the DNA replication and transcription and lead to cell mutation or apoptosis.O6-alkylguanine-DNA alkyltransferase（AGT）is a kind of DNA repair protease that generally exists in the body of mammals.By repairing DNA alkylation damage,AGT causestumor cells to be resistant to chemotherapy drugs and the effect of tumor chemotherapy to be reduced.In this work,the recent progress of the research on the DNA alkylation damage,AGT mediated the resistance of tumor cells,and the application of AGT inhibitors research is summarized.
作者
赵瑞凡
任婷
甄岩
fana;REN Ting;ZHEN Yan(Beijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Bioengi- neering;College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China)
出处
《化学试剂》
CAS
北大核心
2018年第4期305-310,共6页
Chemical Reagents
基金
国家自然科学基金资助项目(21277001)
北京市自然科学基金资助项目(7162015)
