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中性粒细胞/淋巴细胞比值在胃癌诊断中的价值

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摘要 目的探讨中性粒细胞/淋巴细胞比值(NLR)在胃癌诊断中的价值。方法选取天津市人民医院消化内科收治的胃癌患者26例,胃息肉患者34例,慢性胃炎患者38例,总计病例98例。比较3组患者中NLR、CEA、CA199、CA724的水平差异,绘制ROC曲线并且比较NLR及CEA、CA199、CA724等肿瘤标志物的ROC曲线下面积、灵敏度、特异度等相关指标。结果胃癌组CEA、CA199、CA724、NLR水平明显高于胃息肉组和慢性胃炎组,差异有统计学意义(P<0.05);而胃息肉组与慢性胃炎组CEA、CA199、CA724、NLR水平差异均无统计学意义(P>0.05);将NLR与CEA、CA199、CA724比较,ROC曲线下面积差异均无统计学意义(P>0.05);NLR与CEA、CA199、CA724等分别联合作为诊断胃癌指标,其中NLR联合CA199,其ROC曲线下面积为0.830,经检验与CA199的ROC曲线下面积比较差异有统计学意义(P<0.05)。结论 NLR升高反映出胃癌患者的高炎症反应状态,其对胃癌的诊断价值较传统肿瘤标志物并无劣势,并且诊断价值在联合传统肿瘤标志物后有良好提高。
作者 郭小威
出处 《中国城乡企业卫生》 2018年第3期129-131,共3页 Chinese Journal of Urban and Rural Enterprise Hygiene
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