摘要
恶唑烷酮作为一类有效的抗菌化合物,由于其独特的作用机制被用于治疗由耐药菌,尤其是革兰氏阳性菌引起的感染。本文综述了恶唑烷酮类抗菌药物的作用机制及耐药产生机制,以及临床用药安全问题。对于此类化合物的结构修饰和构效关系也将在文中加以阐述。
Oxazolidinoncs are a potent class of synthetic antimicrobial agents with activity mainly against Gram - positive strains. In this re- view, we summarize the mechanism of action and resistance, as well as the safety from clinical experience of oxazolidinones. The structural modi- fications and structure -activitv relationships of oxazolidinones derivatives will also be presented.
作者
冀希炜
孟祥睿
吕媛
曹志成
JI Xi - wei,MENG Xiang - rui2 ,LI Yuan, CHO Chi- shing3(1. Institute of Clinical Pharmacology, Peking University First Hospital, Bering 100191, China ; 2. Intensive Care Unit, Xiyuan Hospital of China Academy of traxtitional Chinese Medicine, Bering 100091, China ;3. Department of Clinical Oncology , Queen Elizabeth Hospital, Hongkong , Chin)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第7期898-902,共5页
The Chinese Journal of Clinical Pharmacology
关键词
恶唑烷酮
革兰氏阳性菌
安全性
耐药性
结构修饰
oxazolidinones
Gram - positive bacteria
safety
antibioticresistance
structural modification
