摘要
目的观察布拉氏酵母菌散剂预防婴幼儿抗菌药物相关性腹泻(antibiotic-associated diarrhea,AAD)的临床疗效。方法将168例应用抗菌药物治疗的支气管肺炎患儿随机分为两组,对照组78例,给予常规抗感染治疗;预防组90例,在对照组常规抗感染治疗基础上加服布拉氏酵母菌散剂,服用剂量:年龄<6月,0.25 g/d;~1岁,0.5 g/d;~3岁,0.5 g/d,均分为2次服用,疗程7~10 d。比较两组腹泻的发生率,观察两组患儿治疗1周后唾液分泌型免疫球蛋白A含量的变化。结果对照组78例发生腹泻34例(43.59%),预防组90例发生腹泻17例(18.89%),两组比较差异有统计学意义(χ2=8.041,P<0.01);对照组发生腹泻次数为(5.38±1.50)次/d,预防组为(3.68±1.10)次/d,两组比较差异有统计学意义(t=3.239,P<0.01);对照组腹泻平均持续时间为(4.84±1.32)d,预防组(3.73±1.33)d,两组比较差异有统计学意义(t=2.245,P<0.05)。1周治疗后,对照组的唾液s Ig A治疗后较治疗前显著降低(t=2.769,P<0.01),而预防组的治疗后与治疗前比较差异无统计学意义(t=0.488,P>0.05)。结论布拉氏酵母菌散剂能有效预防婴幼儿AAD。
Objective To observe the clinical effects of Saccharomyces boulardii sachets in preventing antibi- otic-associated diarrhea (AAD) . Methods 168 child inpatients with bronchopneumonia receiving antibiotic therapy were randomly divided into two groups. The 78 patients in the control group were treated with con- ventional anti-infection therapy, while the 90 patients in the prevention group, based on the above therapy, were given Saccharomyces boulardii sachets, 0.25 g/day for children aged〈6 months, 0.5 g/day for those aged from 6 months to 1 year, 0.5 g/daY for those aged from〉1 year to 3 years, taken orally in 2 times each day for 7 to 10 days. Then the incidence rates of diarrhea in the two groups were compared and the lev- els of salivary secretary IgA (sIgA) at 1 week after treatment were examined. Results 34 patients (43.59%) in the control group vs 13 patients (18.89%) in the prevention group suffered from diarrhea (X^2 = 8. 041, P%0.01) . The diarrhea frequency in control group was 5.38 ± 1.50 times each day while that in prevention group was 3.68±1.10 times each day (t=3. 239, P%O. 01) . The average duration of diar- rhea was 4.84±1.32 days in the control groupvs3.73±l. 33 days in the prevention group (t=2.435, P% 0.05) . After one week of treatment, the level of salivary slgA reduced significantly in control group (t= 2. 769, P〈0.01), but there was no significant change in prevention group (t = 0. 488, P〈0.05) . Conclusion Saccharomvces boulardii sachets can be used to prevent AAD in infants.
作者
林晓晓
蔡喆
林光勇
LIN Xiaoxiao, CAI Zhe, LIN Guangyong(Department of Pharmacy, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou , Zhejiang 325027, Chin)
出处
《中国微生态学杂志》
CAS
CSCD
2018年第3期327-329,337,共4页
Chinese Journal of Microecology
基金
温州市科技计划项目(Y20170159)