乌鲁木齐女性泌尿生殖道支原体感染状况及其耐药性探讨

Female genitourinary tract Mycoplasma infections and its drug resistance in Urumqi women

目的探讨新疆乌鲁木齐市女性泌尿生殖道感染支原体的状况及其耐药情况。方法采用支原体分离培养药敏试剂盒检测2013年7月至2017年8月间7 899例在本院首次就诊的女性患者的泌尿生殖道分泌物样本,分析支原体培养及药敏结果。结果 7 899例女性泌尿生殖道样本中,支原体阳性1 913例,总阳性率为24.22%,其中单纯解脲脲原体(MH-UU+)1 772例,占支原体感染阳性构成比92.63%。民族中,汉族、维吾尔族、回族、哈萨克族、蒙古族中支原体感染率分别为24.18%、22.85%、24.34%、27.94%、24.21%,差异无统计学意义(P>0.05)。单纯人型支原体(MH+UU-)感染对左氧氟沙星、氧氟沙星的耐药率均高于MH-UU+与解脲脲原体和人型支原体混合感染(MH+UU+)(P<0.05)。MH+UU+感染对司巴沙星的耐药率高于MH-UU+和MH+UU-感染(P<0.05)。结论本地区女性泌尿生殖道支原体以MH-UU+感染为主,首选抗生素为交沙霉素,目前在这5个民族感染的支原体体外抗生素耐药性差异不明显。

Objective To explore female genitourinary tract mycoplasma infection and its drug resistance in Urumqi women. Methods The genitourinary tract secretion specimens of 7,899 first-time female patients from July 2013 to August 2017 were detected with mycoplasma cultivation/susceptibility kits. Results 1,913 cases （24.22 %） were mycoplasma positive, including 1,772 cases of single infection of Ureaplasma urealyticum （MH-UU＋）, accounting for 92.63% of total mycoplasma infection. The infection rates of Mycoplasma in Han, Uygur, Hui, Kazak and Mongolian women were 24.18%, 22.85%, 24.34%, 27.94% and 24.21% respectively, with no statistically significant differences （P〉0.05） . The resistance rates to levo- floxacin and ofloxacin in patients with single Mycoplasma hominis infection （MH＋ UU- ） were higher than in those with MH UU＋ and those with both Ureaplasma urealyticum and Mycoplasma hominis infections （MH＋ UU＋） （P〈0.05） . The resistance rate to sparfioxacin in patients with MH＋ UU＋ was higher than in those with MH- UU＋ and those with MH＋ UU （P〈0.05） . Conclusion The main female genitouri- nary tract Mycoplasma infection in Urumqi is single Ureaplasma urealyticum infection, and josamycin is the preferred choice of antibiotics. At present, there are no significant differences in antibiotic resistance among these 5 nationalities in vitro.