肠道菌群与抑郁症相关性的研究进展

Progress in research on intestinal flora associated with depression

正常人体内的肠道菌群数量可达100万亿,可参与人体的多项生理活动,包括营养物质的吸收与代谢、免疫系统的发育与成熟、抵挡外来病原体的入侵等,对人类的健康有着至关重要的作用。近年来发现肠道中的定植微生物与抑郁症、自闭症、焦虑症和帕金森病等一系列的神经精神疾病密切相关。最新研究表明,肠道菌群是通过神经、体液、代谢和免疫多种途径双向调节肠道和中枢神经系统的。目前,随着医学技术和医学理论的的提高,抑郁症与肠道菌群间的关系受到极大地重视。本文从肠道菌群对抑郁症的影响机制以及益生菌对抑郁症的改善作用两方面来综述肠道菌群与抑郁症相关性的最新进展。

The amount of normal intestinal flora in human body may reach up to 100 trillion. Intestinal flora participate in many physiological activities of human body, including the absorption and metabolism of nutri- ents as well as the development and maturity of the immune system, resist the invasion of foreign pathogens, etc. , and play a vital role in maintaining the health of human beings. In recent years, it has been found that the microorganisms in intestinal tract is closely related to a series of neuropsychiatric disorders such as de- pression, autism, anxiety and Parkinson＇s disease. New research showed that intestinal flora take advantage of a two-way regulation on the intestinal and central nervous systems through multiple pathways including nerves, body fluids, metabolism and immunity. At present, with the advancement of medical technology and medical theory, the relationship between depression and intestinal flora has drawn great attention. This paper reviews the recent progress in research on the relationship between intestinal flora and depression from two aspects, the mechanism of influence of intestinal flora and the beneficial effects of probiotics on depression.