莱穆尔-梯曼反应合成2-羟基-1-萘甲醛的研究

Study on the Synthesis of 2-Hydroxy-1-naphthaldehyde by the Remier-Tiemann Reaction

2-羟基-1-萘甲醛是一种重要中间体,很有开发前景和实用价值。以2-萘酚为原料,通过莱穆尔-梯曼反应得到2-羟基-1-萘甲醛。实验考察了反应温度和氯仿的用量对收率的影响,最佳工艺条件:n(2-萘酚)∶n(氯仿)=1∶2.2,反应时间3h,反应温度为70℃。反应收率为63.0%,纯度99.5%。该工艺路线合理,反应时间短,产品收率高。

The 2-hydroxy-1-naphthaldehyde is confirmed as an important intermediate with good development prospect and practical value.The 2-hydroxy-1-naphthaldehyde is synthesized from 2-hydroxynaphthalene by the Reimer-Tiemann Reaction.The effects of temperature and trichloromethane dosage on the yield are discussed.The optimal conditions have been obtained as follows：n（2-hydroxynaphthalene）：n（trichloromethane）=1：2.2,reaction time and temperature is 3 h and 70℃ respectively.The yield is 63.0% with a purity of 99.5%.The process route adopted in the thesis is rational with a short reaction time and high yield.