快通道心脏麻醉技术对心脏手术患者炎症反应和应激状态及神经相关肽的影响

Influences of fast-track cardiac anesthesia on inflammatory response,stress state and neuro-related peptide in patients with cardiac surgery

目的探讨快通道心脏麻醉技术对心脏手术患者炎症反应、应激状态和神经相关肽的影响。方法选取行心脏手术患者50例,随机将其分为干预组和常规组,每组25例。干预组患者行快通道心脏麻醉,常规组患者行常规麻醉。比较两组患者术中炎症反应、应激状态及神经相关肽水平。结果干预组术中肿瘤坏死因子(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)、皮质醇、生长激素、C反应蛋白(CRP)神经元特异性烯醇化酶(NSE)、β-淀粉样蛋白(Aβ)、S100β蛋白(S100β)水平均低于常规组,差异均有统计学意义(P均<0.05)。结论快通道心脏麻醉技术应用于心脏手术,可减轻患者术中炎症反应、应激反应,降低神经相关肽水平,保护心肌细胞。

Objective To investigate the influences of fast-track cardiac anesthesia（ FTCA） on inflammatory response, stress status and neuro-related peptide in patients with cardiac surgery.Methods A total of 50 patients with cardiac surgery were selected and randomly divided into intervention group（ 25 cases） and conventional group（ 25 cases）. The patients in the intervention group were treated by fast channel cardiac anesthesia,and the patients in the conventional group were treated by conventional anesthesia. The inflammatory response,stress status and neuro-related peptide levels in two groups were compared. Results The levels of TNF-α,IL-8,IL-6 cortisol,growth hormone,CRP,NSE,Aβ and S100β of the patients in the intervention group were lower than those in the conventional group,the differences were significant（ P〈0. 05）. Conclusions Fast-track cardiac anesthesia in cardiac surgery patients can reduce the patient＇s intraoperative inflammatory response,stress response and the level of nerve-related peptide and protect the cardiac cells.