调节性B细胞及其在移植耐受与慢性移植物抗宿主病中的免疫调节机制的研究进展

Study on regulatory B cells and its immunomodulatory mechanisms in transplantation tolerance and chronic graft-versus-host disease

慢性移植物抗宿主病（chronic graft versus host disease,cGVHD）是异基因造血干细胞移植最重要的死亡原因。该病与供者免疫活性细胞引起的免疫平衡紊乱及移植免疫耐受异常有关[1]。cGVHD发生率高达40%-70%,近年来因临床造血干细胞移植治疗方案的不断完善以及治疗技术的不断提高,移植早期死亡率逐渐减低,患者长期存活率逐渐增高,cGVHD发病率也有所升高。cGVHD缺乏有效的预防手段,治疗疗程长,生活质量差,故探索有效、

Chronic graft versus host disease（cGVHD）is a common complication of allogeneic hematopoietic stem cell transplantation.It is presented as immune balance disorders and immunological tolerance abnormalities.Regulatory B cells（Bregs）are a newly discovered immunoregulatory cell which can maintain the immune balance,induce transplant tolerance and possess anti-cGVHD effect.In this review,we will outline the evidence,phenotype,activation,immunomodulatory mechanisms of Bregs.Moreover,the regulation effect of Bregs in transplantation tolerance and cGVHD will be discussed.