基因-环境交互作用与疾病风险预测模型研究进展

Gene-environment analysis in the study of chronic non-communicable diseases

慢性非传染性疾病,如肿瘤、心血管疾病、阿兹海默症等,是由遗传因素和环境因素共同作用导致的。在对这类复杂疾病进行风险预测时,若单纯考虑遗传因素或环境因素的贡献往往是不够的,基因-环境的交互作用在其中发挥了重要的作用。针对基因-环境交互作用的研究,需要考虑到多个方面的因素,本文简要介绍这类研究的设计、方法以及经典案例,为未来研究者开展此类研究提供借鉴和帮助。

Chronic non-communicable diseases, such as cancer, cardiovascular diseases and Alzheimer＇s disease are correlated with both genetic and environmental risk factors. However, we would incorrectly estimate the risk if we only considered the separate contributions of genetic or environmental factors. The gene-environment interaction is needed to be considered. There are many aspects need to be considered when we perform the gene-environment interaction analysis. This paper reviews the study design, method and examples of gene-environment interaction analysis and may help researchers to conduct such study in the future.